CAS 81944-09-4: 1(3H)-Isobenzofuranone, 3-butylidene-4,5-dihydro-, (3Z)-

Lactones, nesoi

Z-Ligustilide in acetonitrile is a naturally occurring phytochemical, which is primarily derived from the roots of plants such as Angelica sinensis and Ligusticum chuanxiong. It is an organic compound classified as a volatile phthalide. Its mode of action involves modulating various biochemical pathways, including anti-inflammatory and neuroprotective activities, through mechanisms such as the inhibition of nitric oxide production and the modulation of calcium and reactive oxygen species signaling. The uses and applications of Z-Ligustilide are predominantly within the realm of biomedical research, where it is investigated for its potential therapeutic effects. Notably, it has shown promise in the study of neurodegenerative diseases, cardiovascular disorders, and as an anti-inflammatory agent. Researchers utilize Z-Ligustilide to explore its pharmacological properties and to better understand its efficacy and safety profile as a candidate for therapeutic agent development. It is considered a valuable compound for scientific studies aimed at discovering new treatments for various ailments.

Ligustilide and senkyunolide A, two of the most abundant Ligusticum chuanxiong constituents, have vasorelaxation activities in contractions to various contractile agents in rat isolated aorta.

Lactone

(Z)-Ligustilide inhibits CYP1A1 in human keratinocytes, blocking cancer-causing benzo(a)pyrene via Nrf2.