KW-2478, identified by its CAS number 819812-04-9, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is classified as a small molecule and is known to act as a selective inhibitor of certain protein kinases, which play crucial roles in various cellular processes, including cell growth and division. The compound's structure typically features specific functional groups that contribute to its biological activity and selectivity. KW-2478 has been studied for its efficacy in targeting diseases such as cancer, where aberrant kinase activity is often implicated. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), are essential for determining its suitability for clinical use. Additionally, ongoing research aims to elucidate its mechanism of action and potential side effects, which are critical for assessing its safety profile. Overall, KW-2478 represents a promising candidate in the development of targeted therapies in oncology and other related fields.

KW-2478

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KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.

KW-2478 is a polymerase chain inhibitor that binds to the beta subunit of DNA polymerase. This binding prevents DNA replication, leading to cell death. KW-2477 has been shown to inhibit cancer cells in vitro and in vivo. The drug also synergizes with other chemotherapeutic drugs such as doxorubicin, cisplatin, or vincristine by binding to the ATP-binding cassette transporter. KW-2478 has been shown to be safe and effective in treating diarrhoea, which may be due to its ability to inhibit P-glycoprotein at the intestinal epithelium level.

CAS 819812-04-9: KW-2478

KW-2478

Ref: 54-BUP07556

KW-2478

Ref: TM-T6558

KW-2478

Ref: TR-K660453

KW-2478

Ref: IN-DA00G6XG

KW-2478

Ref: 3D-UHB81204