CAS 82-07-5: Xanthene-9-carboxylic acid

Xanthene-9-carboxylic acid (XCA) is a molecule that is derived from the amino acid tryptophan. It has been shown to inhibit the activity of protein kinase A, which is an enzyme that regulates the production of cyclic AMP (cAMP). The chemical structure of XCA contains a hydroxy group, a carboxylate, and a proton on the propantheline ring. This compound has been shown to have pharmacokinetic properties in rats and humans. XCA is excreted in urine as unchanged drug and metabolites, with hydroxylation by cytochrome P450 enzymes being rate-limiting for its metabolism. XCA also has an ampk activator effect, which can be seen in cells treated with adenosine monophosphate or phosphoramidon.

Aromatic heterocyclic pesticides with oxygen hetero-atom(s) only, nesoi

Applications Xanthene-9-carboxylic Acid is xanthrene derivative that is capable of inhibiting the TTR conformational changes facilitating amyloid fibril formation. References Baures, P.W., Bioorg. Med. Chem., 6, 1389 (1998);

9H-Xanthene-9-carboxylic acid

Transesterification of the ethyl ester of commercially available xanthene-9-carboxylic acid yeildits 3- quinuclidinyl ester. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.