CAS 821768-06-3: 1-Piperazinecarboxamide,4-[3-(trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-

JNJ-17203212

JNJ-17203212 is a pharmacological compound, specifically a selective antagonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. This compound is derived from synthetic chemical processes, emphasizing its role in modulating ion channel activity. The TRPV1 receptor is a non-selective cation channel expressed predominantly in sensory neurons. The mode of action of JNJ-17203212 involves blocking the TRPV1 receptor, which in turn inhibits the receptor's response to its typical agonists like capsaicin, protons, and heat. This antagonistic action impedes the influx of cations, particularly calcium ions, which are vital for the excitation of sensory neurons involved in nociceptive pathways. The primary application of JNJ-17203212 is in scientific research focused on pain management. By inhibiting TRPV1, this compound is utilized for exploring novel therapeutic avenues for conditions associated with chronic pain and inflammation. Its ability to modulate sensory neuron activity makes it a significant tool in elucidating the pathophysiology of pain and developing potential analgesic strategies.

JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).

Applications JNJ 17203212 is a high affinity TRPV1 receptor antagonist.

JNJ-17203212