CAS 83-12-5: Phenindione

Phenindione impurity 1

Phenindione

2-Phenyl-1,3-indandione is a coumarin derivative that is used as an anti-inflammatory drug. It inhibits the release of arachidonic acid from phospholipids in the cell membrane and consequently inhibits the formation of prostaglandins. The drug has been shown to inhibit light-induced tumor promotion in mice with cervical cancer, which may be due to its ability to inhibit the activity of oxidative enzymes such as cytochrome P450. 2-Phenyl-1,3-indandione also inhibits sodium-dependent glucose transport and energy metabolism by binding to potassium channels. This drug also has immunosuppressive effects on lymphocyte transformation and autoimmune diseases through hydrogen bonding interactions with protein molecules.

2-Phenyl-1,3-Indandione

Phenindione, an obsolete anticoagulant with warfarin-like effects, is rarely used due to severe side effects.

Applications Phenindione is a proton pump inhibitor and traditional nonsteroidal anti-inflammatory drug used for acute interstitial nephritis and acute kidney injury. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Leonard, C.E., et al.: Pharmacoepidemiol. Drug. Safety., 21, 1155 (2012); Moda, T.L., et al.: Bioorg. Med. Chem. Lett., 22, 2889 (2012); Dhareshwar, S.S., et al.: J. Pharma. Sci., 99, 2711 (2010);