CAS 836683-15-9: Benzamide,3-[5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl]-N-cyclopropyl-4-methyl-

Acumapimod is an anti-inflammatory drug that has been shown to be effective in the treatment of inflammatory diseases, such as rheumatoid arthritis. It is a 2-adrenergic receptor agonist that inhibits the production of reactive oxygen species by inhibiting the enzyme xanthine oxidase. Acumapimod also has an inhibitory effect on other pro-inflammatory mediators, such as histamine, leukotrienes, and prostaglandins. Acumapimod has been shown to be effective in reducing inflammation and pain in animal models of cancer. It has also been shown to inhibit tumor growth and induce cell death in vitro. Acumapimod is used to treat inflammatory diseases because it blocks the production of reactive oxygen species, which are involved in tissue damage caused by inflammation. This drug binds with high affinity to the amide group on the 2-adrenergic receptor and inhibits the binding of ligand molecules, preventing cellular activation and

Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).

Acumapimod

Acumapimod