CAS 83881-08-7: Pregna-1,4-diene-3,20-dione,21-chloro-9,11-epoxy-17-hydroxy-16-methyl-, (9b,11b,16a)-

Impurity Mometasone Impurity Q Applications An intermediate in the synthesis of deuterated Mometason Furoate, a topical corticosteroid intermediate of used as an anti-inflammatory. References Shapiro, E.L., et al.: J. Med. Chem., 30, 1581 (1987), Graft, D., et al.: J. Allergy Clin. Immunol., 98, 724 (1996)

Applications 17α-Hydroxy-21-chloro-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione-d5 is an intermediate in synthesizing Mometasone-d5 (M489997), an Isotope labelled analogue of Mometasone (M489995), a potent topical corticosteroid. Mometasone has potent antiinflammatory activity and is used in the treatment of dermatological disorders. References Schulz, M. et al.: Pharm. Zeit., 139, 28 (1994); Prakash, A. et al.: Drugs, 55, 145 (1998);