CAS: 84211-05-2

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Mafosfamide, a synthetic antineoplastic, alkylates DNA without needing liver activation. Useful for neoplastic meningitis.

Stability Moisture Sensitive, Very Hygroscopic Applications A Cyclophosphamide analog which induces apoptosis dose and time dependently in lymphoblastoid cells, with clearly more apoptosis in p53wt cells. Antitumor agent. References Roy, P., et al.: Drug Metab. Dispos., 27, 655 (1999), Lips, J., et al.: Carcinogenesis, 22, 579 (2001), Ward, I., et al.: J. Biol. Chem., 276, 47759 (2001), Zhou, B., et al.: Cancer Biol. Ther., 2, S16 (2003), Roos, W., et al.: Oncogene, 26, 186 (2007),