CAS 843666-40-0: Octadecanedioic acid,1-(1,1-dimethylethyl) ester

Applications 18-(tert-Butoxy)-18-oxooctadecanoic Acid is used to engineer long-acting, potent exendin-4 based GLP-1 analog for microstructure-based transdermal delivery for glycemic control. References Yang, P., et al.: Proc. Natl. Acad. Sci. USA, 113, 4140 (2016);

18-(tert-Butoxy)-18-oxooctadecanoic acid

18-(Tert-butoxy)-18-oxooctadecanoic acid is a synthetic intermediate that has been used to synthesize semaglutide. It can be produced by the catalytic effect of ethyl bromoacetate on 18-hydroxyoctadecanoic acid in the presence of formamide and magnetic trifluoroacetic acid. The reaction time for the synthesis is 2 hours and produces high yields with a solid-phase synthesis. The product can be recycled, which reduces waste and cost. The product is also catalytically active and has a long shelf life.

Boc-C16-COOH

Boc-C16-COOH is a alkyl-chain-based PROTAC linker. Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).