CAS: 843782-19-4

Endogenous agonist for NMU receptors (EC50: NMU1=65 pM, NMU2=91 pM), shifts locomotor circadian rhythm, suppresses appetite.

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Neuromedin S (Rat) is a peptide that is a potent inhibitor of protein interactions. It binds to the extracellular domain of the receptor and blocks its interaction with the ligand. This can be used as a research tool for studying the role of proteins in cell biology, pharmacology, or ion channels. Neuromedin S (Rat) is a high-purity peptide with CAS No. 843782-19-4 that has been shown to inhibit ligand binding to receptors in vitro and in vivo. Neuromedin S (Rat) also inhibits agonist-induced activation of ion channels at micromolar concentrations and blocks voltage-gated sodium currents at nanomolar concentrations. It has been used to study the role of neurexins in transmission at synapses between neurons by blocking their interaction with neuroligins.