CAS 845614-11-1: Bitopertin
Formula:C21H20F7N3O4S
InChI:InChI=1S/C21H20F7N3O4S/c1-12(20(23,24)25)35-17-4-3-14(36(2,33)34)10-15(17)19(32)31-7-5-30(6-8-31)18-16(22)9-13(11-29-18)21(26,27)28/h3-4,9-12H,5-8H2,1-2H3/t12-/m0/s1
InChI key:InChIKey=YUUGYIUSCYNSQR-LBPRGKRZSA-N
SMILES:C(=O)(C1=C(O[C@H](C(F)(F)F)C)C=CC(S(C)(=O)=O)=C1)N2CCN(CC2)C3=C(F)C=C(C(F)(F)F)C=N3
Synonyms:- (S)-[4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-(methanesulfonyl)-2-(2,2,2-trifluoro-1-methylethoxy)phenyl]methanone
- (S)-[4-(3-fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone
- Methanone, [4-[3-fluoro-5-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl][5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl]-
- Piperazine, 1-[3-fluoro-5-(trifluoromethyl)-2-pyridinyl]-4-[5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]benzoyl]-
- R 1678
- Rg 1678
- Ro 4917939
- [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-Methylsulfonyl-2-[((S)-2,2,2-trifluoro-1-methylethyl)oxy]phenyl]methanone
- [4-(3-fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone
- [4-[3-Fluoro-5-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl][5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl]methanone
- [4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-[5-methylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methanone
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Found 4 products.
[4-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]piperazin-1-yl]-[5-methylsulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)phenyl]methanone
CAS:Bitopertin is a drug that inhibits the activity of glycine and glutamate receptors, which are important for neurotransmission. It has been shown to be effective in treating schizophrenia in an intent-to-treat population. Bitopertin is not toxic at doses up to 2000 mg/kg, but has been shown to have interactions with other drugs. This drug binds to the glycine receptor and blocks the glycine binding site, thereby inhibiting postsynaptic actions of glycine. Bitopertin also interacts with the glutamate receptor by binding competitively to the glutamate binding site on the NMDA receptor complex, thereby blocking ion flux through this channel. In addition, bitopertin has inhibitory properties against nicotinic acetylcholine receptors.END>Purity:Min. 95%Ref: 3D-FF43104
Discontinued productBitopertin
CAS:Bitopertin (Paliflutine) (RG1678, RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nMFormula:C21H20F7N3O4SPurity:98.57% - 98.71%Color and Shape:SolidMolecular weight:543.46[4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-Methylsulfonyl-2-[((S)-2,2,2-trifluoro-1-methylethyl)oxy]phenyl]methanone
CAS:Formula:C21H20F7N3O4SPurity:99%Color and Shape:SolidMolecular weight:543.455
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