Cyclobutylboronic acid is an organoboron compound characterized by the presence of a cyclobutane ring and a boronic acid functional group. It typically appears as a colorless to pale yellow liquid or solid, depending on its form and purity. This compound is known for its ability to form stable complexes with various substrates, making it valuable in organic synthesis, particularly in cross-coupling reactions such as Suzuki-Miyaura coupling. Cyclobutylboronic acid exhibits moderate solubility in polar organic solvents, and its reactivity is influenced by the boron atom, which can participate in nucleophilic and electrophilic reactions. The presence of the cyclobutane ring introduces unique steric and electronic properties, which can affect its reactivity and selectivity in chemical transformations. Additionally, cyclobutylboronic acid is of interest in medicinal chemistry and materials science due to its potential applications in drug development and the synthesis of novel materials. Proper handling and storage are essential, as boronic acids can be sensitive to moisture and air.

cyclobutylboronic acid

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Cyclobutylboronic acid is a metabolite of cyclobutanone and has been shown to have inhibitory effects on metabolic disorders in mammalian cells. Cyclobutylboronic acid is an inhibitor of the enzyme phosphofructokinase-1 (PFK-1). This inhibition reduces the production of glucose from fructose, leading to insulin resistance. Cyclobutylboronic acid also inhibits inflammatory diseases by inhibiting the activity of proinflammatory cytokines and chemokines. The structural formula for cyclobutylboronic acid is shown below.

CAS 849052-26-2: cyclobutylboronic acid

Cyclobutylboronic acid

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Cyclobutaneboronic acid

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Cyclobutylboronic acid

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Cyclobutylboronic acid

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