CAS: 849214-04-6

3',3'-Cyclic guanosine monophosphate-adenosine monophosphate is a molecule that is a stimulator of lymphocytic leukemia. It has been shown to induce chronic lymphocytic leukemia in mice and humans, which is an indication of its clinical relevance. 3',3'-Cyclic guanosine monophosphate-adenosine monophosphate induces cancer by inhibiting the production of cyclic nucleotide phosphodiesterases, which are enzymes that break down cyclic nucleotides. This leads to elevated levels of cyclic nucleotides and an increase in intracellular cAMP levels. The anticancer effect of 3',3'-cyclic guanosine monophosphate-adenosine monophosphate may also be due to its ability to inhibit the growth factor activity of staphylococcus aureus.

cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.

Applications c-GpAp induces the production of interferons, a usual response to triggers in the cytoplasm of mammalian cells by the presence of DNA. References Sun, L. et al.: Science, 339, 786 (2013);