![4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phe…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fcas-image%2Fthumb-webp%2F298736-4-4-4-chloro-11-biphenyl-2-yl-methyl-1-piperazinyl-n-4-1r-3-dimethylamino-1-phenylthio-methyl-propyl-amino-3-nitrophenyl-sulfonyl-benzamide.webp&w=3840&q=75)
CAS 852808-04-9: 4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
Formula:C42H45ClN6O5S2
InChI:InChI=1S/C42H45ClN6O5S2/c1-46(2)23-22-35(30-55-37-9-4-3-5-10-37)44-40-21-20-38(28-41(40)49(51)52)56(53,54)45-42(50)32-14-18-36(19-15-32)48-26-24-47(25-27-48)29-33-8-6-7-11-39(33)31-12-16-34(43)17-13-31/h3-21,28,35,44H,22-27,29-30H2,1-2H3,(H,45,50)/t35-/m1/s1
InChI key:InChIKey=HPLNQCPCUACXLM-PGUFJCEWSA-N
SMILES:C(C1=C(C=CC=C1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC=C(C(NS(=O)(=O)C5=CC(N(=O)=O)=C(N[C@@H](CSC6=CC=CC=C6)CCN(C)C)C=C5)=O)C=C4
Synonyms:- 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
- 852808-04-9
- Abt 737
- Benzamide, 4-[4-[(4′-chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-
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(R)-4-(4-((4'-Chloro-[1,1'-Biphenyl]-2-Yl)Methyl)Piperazin-1-Yl)-N-((4-((4-(Dimethylamino)-1-(Phenylthio)Butan-2-Yl)Amino)-3-Nitrophenyl)Sulfonyl)Benzamide
CAS:(R)-4-(4-((4'-Chloro-[1,1'-Biphenyl]-2-Yl)Methyl)Piperazin-1-Yl)-N-((4-((4-(Dimethylamino)-1-(Phenylthio)Butan-2-Yl)Amino)-3-Nitrophenyl)Sulfonyl)BenzamidePurity:98%Molecular weight:813.43g/molABT-737
CAS:ABT-737 is a BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w. ABT-737 exhibits antitumor activity and anti-aging activity. Cost-effective and quality-assured.Formula:C42H45ClN6O5S2Purity:100% - 99.73%Color and Shape:SolidMolecular weight:813.43ABT 737
CAS:Controlled ProductApplications A selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions in tumors derived from some SCLC cell lines. Potent Bcl-2 Family inhibitor. References Ikegaki, N., et al.: Cancer Res., 54, 6 (1994), Kaiser, U., et al.: Lung Cancer, 15, 31 (1996), Rudin, C., et al.: J. Clin. Oncol., 22, 1110 ( 2004), Konopleva, M., et al.: Cancer Cell, 10, 375 (2006), Trudel, S., et al.: Clin. Cancer Res., 13, 621 (2007),Formula:C42H45ClN6O5S2Color and Shape:Off-WhiteMolecular weight:813.43ABT 737
CAS:Inhibits anti-apoptotic proteins Bcl-2, Bcl-xl and Bcl-w. Synergistic with chemotherapy and radiotherapy in several tumour cell lines. Potent activity as a single agent in lymphoid cancer and small cell lung cancer (SCLC) cell lines. Causes tumour regression in SCLC xenograft tumour in vivo.Formula:C42H45ClN6O5S2Purity:Min. 95%Color and Shape:Yellow SolidMolecular weight:813.43 g/mol
![(R)-4-(4-((4'-Chloro-[1,1'-Biphenyl]-2-Yl)Methyl)Piperazin-1-Yl)-N-((4-((4-(Dimethylamino)-1-(Phen…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FOR1023267.jpg&w=3840&q=75)
