CAS: 854038-96-3

Norcaesalpinin E shows antimalarial activity against the malaria parasite Plasmodium falciparum FCR-3/A2 clone in vitro, with an IC50 value of 0.090 microM.

Norcaesalpinin E is a naturally occurring compound, which is a type of flavonoid derived from the plant genus Caesalpinia. These plants are part of the Leguminosae family, widely recognized for their diverse secondary metabolites with significant biological activities. Norcaesalpinin E exerts its effects primarily through modulation of inflammatory pathways, specifically by inhibiting the production of certain pro-inflammatory cytokines. This mode of action suggests its potential as a modulator of inflammatory responses, making it of particular interest in the study of chronic inflammatory diseases. The compound has been investigated for its pharmacological properties, particularly its applications in reducing inflammation and associated symptoms. Interest in Norcaesalpinin E is growing within the scientific community due to its potential use in the treatment of diseases where inflammation plays a key role, such as arthritis and other autoimmune conditions. Further research is ongoing to fully elucidate its mechanisms of action and to explore additional therapeutic applications.