Mono-iodo amiodarone, identified by its CAS number 85642-08-6, is a derivative of amiodarone, a well-known antiarrhythmic medication. This compound features a unique structure characterized by the presence of iodine atoms, which contribute to its pharmacological properties. Mono-iodo amiodarone is primarily recognized for its role in the treatment of various cardiac arrhythmias, particularly in patients with atrial fibrillation or ventricular tachycardia. The iodine atoms in its structure enhance its lipophilicity, allowing it to accumulate in cardiac tissues and exert its therapeutic effects. Additionally, this compound exhibits a complex mechanism of action, involving the blockade of potassium channels and modulation of adrenergic receptors, which helps restore normal heart rhythm. Its pharmacokinetics are influenced by its high protein binding capacity and long half-life, making it effective for long-term management of arrhythmias. However, like other iodine-containing compounds, it may pose risks of thyroid dysfunction, necessitating careful monitoring during treatment. Overall, mono-iodo amiodarone represents a significant advancement in antiarrhythmic therapy.

Mono-iodo amiodarone

85642-08-6: 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3-iodophenyl ketone

Impurity Amiodarone EP Impurity C /Amiodarone USP Related Compound C
Applications An intermediate of Amiodarone (A632950). Amiodarone EP Impurity C
References Weir, S., et al.: J. Pharm. Sci., 74, 460 (1985), Ramanathan, R., et al.: Anal. Chem., 72, 1352 (2000),


Deiodo Amiodarone

Deiodo amiodarone is a noncompetitive inhibitor that binds to the active site of the enzyme and blocks the binding of substrate, thereby inhibiting the synthesis of catecholamines. Deiodo amiodarone has been shown to inhibit the oxidation of benzofuran derivatives in rat liver microsomes, human liver tissue samples, and chromatographic conditions. The inhibition constant for deiodo amiodarone was determined by liquid chromatography with a homogenizing technique.

Deiodo amiodarone

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

CAS 85642-08-6: Mono-iodo amiodarone

Deiodo Amiodarone

Ref: TR-D229025

Deiodo amiodarone

Ref: 3D-ID20972

Monoiodoamiodarone ((2-Butylbenzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3-iodophenyl}methanone)

Ref: 45-1A01090

Amiodarone Related Compound C

Ref: 45-1027335