CAS: 863421-32-3

TM 6089 is a natural triterpenoid that has been shown to have immunosuppressive and anti-inflammatory properties. TM 6089 is able to inhibit the activity of hydroxylases, which are enzymes that break down cortisone. The hydrocortisone acetate (HC) metabolite of TM 6089 has been shown to be effective in treating infectious diseases, cancer, and acute kidney injury. Hydrocortisone acetate has also been shown to be an effective treatment for inflammatory bowel disease through its inhibition of the growth factor erythropoietin. TM 6089 also inhibits the production of other pro-inflammatory cytokines such as interleukin-1β, tumor necrosis factor-α, and interferon-γ.

TM6089

TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.