CAS 866083-42-3: 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, (1S,3S,5S)-

Applications Saxagliptin hydrochloride monohydrate, an anti-diabetic drug can be synthesized using a coupling reaction of (S)-phthalimido-(3-hydroxy-adamantan-1-yl)acetic acid with (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-nitrile followed by removal of the phthalimide protecting group and treatment with HCl. References Kovi, Ravishanker, et al.: Apicore, LLC, WO 2012162507 (2012)