CAS: 868612-83-3

IN-1130

IN-1130: ALK5 inhibitor, IC50 - 5.3 nM (Smad3), 36 nM (casein), 4.3 μM (p38α MAPK).

IN 1130 is a molecule that has been shown to have antimicrobial effects against bacteria. It has been observed to inhibit the growth of prostate cancer cells, as well as decrease the disease activity of abdominal surgery patients. The mechanism of action is not fully understood, but it is hypothesized that IN 1130 is a growth factor-β1 agonist that inhibits the proliferation of tumor cells by binding to its receptor and activating intracellular signaling pathways. IN 1130 has also been shown to exhibit an effect on hematopoietic cells in vitro, with potential applications in pediatric and optical sensor technology. In addition, IN 1130 has been observed to be effective in treating cervical cancer with hydroxyl groups on the molecule that can react with histochemical stains.