(D-Pro4, D-Trp7,9,10)-substance P*fragment 4-11, with the CAS number 86917-57-9, is a synthetic peptide derived from substance P, a neuropeptide involved in pain perception and inflammatory processes. This compound features specific amino acid substitutions, including D-proline at position 4 and D-tryptophan at positions 7, 9, and 10, which enhance its stability and bioactivity compared to the natural peptide. The modifications aim to improve its pharmacological properties, such as receptor binding affinity and resistance to enzymatic degradation. Characteristically, this peptide exhibits neurokinin receptor activity, influencing various physiological responses, including pain modulation and neurogenic inflammation. Its structure typically includes a sequence of amino acids that contribute to its biological function, and it is often studied for its potential therapeutic applications in pain management and other neurogenic conditions. As a synthetic analog, it is primarily used in research settings to explore the mechanisms of neuropeptide action and to develop new analgesic drugs.

(D-pro4,D-trp7,9,10)-substance P*fragment 4-11

86917-57-9: (D-Pro4,D-Trp7910)-Substance P (4-11), H-D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2

Substance P is a neuropeptide that is found in the central nervous system. It is also found in the gastrointestinal tract and plays a role in the regulation of smooth muscle contraction. Substance P has been shown to be involved in inflammatory responses, immune responses, and regulation of water and electrolyte balance. The maximal response of substance P occurs at concentrations between 0.1 to 1 nM and its inhibitory effect on the apical Ca2+ response occurs at concentrations between 10-100 nM. In addition, substance P has been shown to have an excitatory effect on 5-HT7 receptors with subunit composition GluN1/GluN2A/GluN2B/GluN3A/5-HT7(H).

CAS 86917-57-9: (D-pro4,D-trp7,9,10)-substance P*fragment 4-11

(D-Pro4,D-Trp7·9·10)-Substance P (4-11)

Ref: 3D-FP109336