CAS: 869769-98-2

INCB-9471 is a CCR5 antagonist with anti-HIV activity and inhibits the interaction between HIV-1 gp120.

INCB9471 is a drug that inhibits the activity of human immunodeficiency virus (HIV) by binding to the viral reverse transcriptase enzyme. It has been shown to be active against HIV-1 and HIV-2, with low cytotoxicity for cells in vitro. INCB9471 can be used for the treatment of bone cancer or as a diagnostic agent for infectious diseases, such as tuberculosis or hepatitis B. The compound has not been tested in animals or humans for long-term toxicity, bowel disease, primary sclerosing cholangitis, or antiviral resistance. However, it has been shown to be efficacious in treating her2+ breast cancer and long-term efficacy (up to 3 years) in patients with chronic hepatitis C.

INCB-9471