CAS 87-44-5: (-)-Caryophyllene

Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders, TC has effect on kainic acid-induced seizure activity caused by oxidative stress and pro-inflammation, and significantly inhibits KA-induced generation of malondialdehyde, TC exert cerebral anti-inflammatory effects by mitigating the expression of proinflammatory cytokines, such as TNF-α and IL-1β; suggest that TC has a potential protective effect on chemical induced seizure and brain damage.

Beta-Caryophyllene is a bicyclic sesquiterpene, which is a natural product found in essential oils derived from various plants, including black pepper, cloves, and cannabis. This compound is characterized by its unique ability to selectively bind to cannabinoid receptor type 2 (CB2), acting as a full agonist. Unlike typical cannabinoids, beta-Caryophyllene does not interact substantially with CB1 receptors, making it non-psychoactive. The mode of action of beta-Caryophyllene involves the activation of CB2 receptors, which are predominantly expressed in peripheral tissues and immune cells. This activation leads to a cascade of anti-inflammatory and analgesic responses, providing a basis for its therapeutic potential in managing conditions such as inflammatory disorders, pain, and some neurodegenerative diseases. In scientific applications, beta-Caryophyllene is studied for its role in modulating inflammation and providing analgesia without the central nervous system effects associated with other cannabinoids. Further research explores its potential in enhancing the effectiveness of other therapeutic agents and its impact on gut health by interacting with the gut microbiota. Its natural origin and specific CB2 receptor activity make it a compound of interest in the development of novel therapeutic strategies.

β-Caryophyllene

(-)-trans-Caryophyllene analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Alicyclic hydrocarbon

Purity min. 98%

β-Caryophyllene

Stability Light Sensitive Applications β-Caryophyllene is notable for having a cyclobutane ring, a rarity in nature. β-Caryophyllene is one of the chemical compounds that contributes to the spiciness of black pepper. β-Caryophyllene was shown to selectively bind to the cannabinoid receptor type-2 (CB2) and to exert significant cannabimimetic antiinflammatory effects in mice. References Kaul, P.N., et al.: J. Sci. Food Agric., 83, 53 (2003); Singh, G., et al.: J. Agric. Food Chem., 54, 174 (2006);