CAS 874-05-5: 1H-Indazol-3-amine

Applications 1H-Indazol-3-amine is a reagent used in the preparation of indazole derivatives as potential antimicrobial and antitumor agents. References Plescia, S., et al.: ARKIVOC, 10, 163 (2010)

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

3-Amino-1H-indazole

1H-Indazol-3-ylamine is a novel drug that has been shown to inhibit the Abl kinase. The drug binds to the ATP binding site at the N-terminus of the kinase and prevents ATP from activating the kinase. It also inhibits the phosphorylation of Bcr-Abl, which is essential for its growth and survival. 1H-Indazol-3-ylamine has been shown to be active against cells with a high level of bcr-abl kinase activity, such as K562 leukemia cells, in transfection experiments. This drug also inhibits Bcr-Abl tyrosine phosphorylation and blocks signals downstream of Bcr-Abl, such as protein synthesis and cell division. 1H-Indazol-3-ylamine has been found to have potential anticancer activity against atherosclerotic cardiovascular disease (CVD) in mice models by inhibiting lipid accumulation in