CAS: 88247-69-2

Applications 25-Hydroxy Cholesterol-d6, is the labeled analogue of 25-Hydroxy Cholesterol (H918030), which is an oxygenated derivative of Cholesterol (C432501); an oxysterol. An inhibitor of human immunodeficiency virus replication in vitro. It also induces apoptosis in human monocytic cell lines as well as inducing apoptosis in CEM cells associated with negative regulation of c-Myc. References Aupeix, K. et al.: Immunobiology, 194, 415 (1995); Moog, C. et al.: Antivir. Chem, Chemother., 9, 491 (1998); Ayala-Torres, S. et al.: Exp. Cell Res., 246, 193 (1999);

25-Hydroxy cholesterol-D6 is a pharmaceutical that is used in clinical settings. It can be used to measure the levels of oxysterols such as 25-hydroxycholesterol and 24,25-dihydroxycholesterol in blood plasma or cerebrospinal fluid. In addition, it can be used to detect the presence of oxysterols in red blood cells. This product has been shown to inhibit demyelination by preventing myelin sheath formation and also inhibits the production of an inflammatory molecule called tumor necrosis factor alpha (TNFα) in response to lipopolysaccharide (LPS).