CAS 88321-09-9: Loxistatin
Formula:C17H30N2O5
InChI:InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
InChI key:InChIKey=SRVFFFJZQVENJC-IHRRRGAJSA-N
SMILES:C(N[C@H](C(NCCC(C)C)=O)CC(C)C)(=O)[C@@H]1[C@@H](C(OCC)=O)O1
Synonyms:- 2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-
- Aloxistatin
- E 64c ethyl ester
- E-64d
- E64d
- E64d/pepstatin
- EST
- EST (pharmaceutical)
- Ep 453
- Loxistatin
- NSC 694281
- See more synonyms
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Found 11 products.
E-64d
CAS:Controlled ProductApplications E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to interfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats. References Wilcox, D. et al.: Biochem. J., 285, 495 (1992); McGowan, E.B. et al.: Biochem. Biophys. Res. Comm., 158, 432 (1989); Tsubokawa, T. et al.: J. Neurosci. Res., 84, 832 (2006);Formula:C17H30N2O5Color and Shape:NeatMolecular weight:342.43L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester
CAS:E64d (EST), a membrane permeable analog of E64c, was expected to be useful as an oral drug for muscular dystrophy due to its potent inhibitory activities against the cysteine proteinases involved in the myofibrillar protein degradation that occurs in this disease. E64d attenuates the effects of parathyroid hormone on osteoblasts in vitro. By inhibiting cathepsin B, a cysteine protease showing β-secretase activity, E64d could reduce brain Aβ and improve memory deficits in Alzheimer’s disease animal models.Formula:C17H30N2O5Purity:> 99%Color and Shape:WhiteMolecular weight:342.44L-TRANS-EPOXYSUCCINYL-LEU-3-METHYLBUTYLAMIDE-ETHYL ESTER
CAS:Purity:95.0%Molecular weight:342.4360046386719E-64d
CAS:E-64dFormula:C17H30N2O5Purity:98.8% (hplc) (Typical Value in Batch COA)Color and Shape:PowderMolecular weight:342.43g/molAloxistatin
CAS:Aloxistatin (E64d) inhibits cysteine proteases, blocks calpain in platelets, and prevents blood clotting.Formula:C17H30N2O5Purity:98.12% - 99.47%Color and Shape:SolidMolecular weight:342.43Ref: TM-T6040
1mg43.00€2mg56.00€5mg88.00€10mg119.00€25mg188.00€50mg350.00€100mg522.00€500mg1,130.00€1mL*10mM (DMSO)70.00€(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester
CAS:Inhibitor of cathepsinsFormula:C17H30N2O5Purity:Min. 95%Color and Shape:PowderMolecular weight:342.43 g/molE-64d [for Biochemical Research]
CAS:Formula:C17H30N2O5Purity:>95.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:342.44E-64d protease inhibitor
CAS:Formula:C17H30N2O5Purity:≥ 95.0%Color and Shape:White powderMolecular weight:342.43E-64-d
CAS:E-64-d is a research tool that is used in cell biology, pharmacology, and biochemistry to study protein interactions. E-64-d is an activator, ligand, or receptor for ion channels and has been shown to inhibit the activity of high purity K+ channels. This peptide binds to the extracellular loop of voltage-gated potassium channels (Kv1.2) and inhibits the opening of these channels by blocking their access to ATP. E-64-d also binds to an antibody as a competitive inhibitor of the antigen binding site on the antibody.Formula:C17H30N2O5Purity:Min. 95%Molecular weight:342.43 g/mol
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