CAS 885051-07-0: (2R)-2-phenyl-2,3-dihydroimidazo[2,1-b][1,3]benzothiazole

(2R)-2-Phenyl-2,3-dihydroimidazo[2,1-b][1,3]benzothiazole

Benzotetramisole is a nonsteroidal anti-inflammatory drug (NSAID) that has been shown to be effective in the immobilization of rats and mice. It is an enantiopure compound with kinetic, nucleophilic, and ring-opening properties. Benzotetramisole is synthesized from β-amino acid, which undergoes a series of reactions including methanolysis, reductive amination, and ring-opening to yield the desired product. This reaction proceeds with only one enantiomer due to the presence of a chiral center on the molecule. The stereoselectivity was achieved through steric interactions at the nucleophilic site.