CAS 88901-43-3: b-D-Glucopyranoside, (3b,9b,10a,11a,24R)-24-(b-D-glucopyranosyloxy)-11,25-dihydroxy-9-methyl-19-norlanost-5-en-3-yl6-O-b-D-glucopyranosyl-

Mogroside III-A2 inhibits with IC50 of 346-400 mol/32 pmol TPA and weakly blocks NOR 1, a NO donor.

Mogroside III-A2 is a natural sweetener compound, which is an extract derived from the fruit of Siraitia grosvenorii, commonly known as monk fruit or Luo Han Guo. This compound is a member of the mogrosides, a group of triterpene glycosides known for their intense sweetness, up to hundreds of times sweeter than sucrose. Mogroside III-A2 functions by interacting with taste receptors on the tongue, specifically engaging with the T1R2/T1R3 sweet receptor complex, eliciting a perception of sweetness without caloric contribution. Its non-glycemic nature makes it an attractive sweetening agent for individuals requiring glycemic control, such as those managing diabetes. The applications of Mogroside III-A2 extend beyond sweetening, primarily due to its antioxidant properties, which may contribute to its potential anti-inflammatory and anti-carcinogenic effects. It is the subject of ongoing research in pharmacology and nutraceuticals, exploring its role in oxidative stress reduction and metabolic regulation. Scientists are particularly interested in the bioactivity of mogrosides for functional food formulation and the development of natural health-promoting products.