CAS 890302-02-0: 2-aMino-6-(trifluoroMethyl)nicotinic acid

2-Amino-6-(trifluoromethyl)pyridine-3-carboxylic acid is a non-nucleoside inhibitor of the viral polymerase. It has been shown to inhibit the replication of HIV, HSV, and HBV in cell-based assays. This drug also has significant cytotoxic effects on cells that are not infected with herpesviruses. The selectivity index for 2-amino-6-(trifluoromethyl)pyridine-3-carboxylic acid is constant and it does not interact with any cellular proteins or enzymes other than those involved in viral replication. 2-Amino-6-(trifluoromethyl)pyridine-3-carboxylic acid inhibits the infectivity of HIV, HSV, and HBV by binding to the RNA template of these viruses and blocking their ability to replicate. This drug is also resistant to