CAS: 894804-07-0

JNK Inhibitor VIII

Applications JNK Inhibitor VIII is an inhibitor shown to suppress apoptosis, caspase cleavage, and cytochrome C release.

JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,

N-(4-Amino-5-Cyano-6-Ethoxypyridin-2-Yl)-2-(2,5-Dimethoxyphenyl)Acetamide

JNK inhibitor VIII is a potent, selective and cell-permeable JNK inhibitor that is effective in inhibiting the activation of pro-inflammatory genes. It has been shown to inhibit the proliferation and induce apoptosis in leukemia cells, as well as blocking the growth of primary human prostate cancer cells. JNK inhibitor VIII blocks ubiquitin ligases involved in protein degradation and mitochondrial membrane potential, which induces reactive oxygen species (ROS) production by mitochondria. This leads to an increase in cytosolic Ca2+, c-jun phosphorylation, and potential drug target for cancer therapy.