Ethyl 5-(2,2,2-trifluoroacetyl)thiophene-2-carboxylate is a chemical compound characterized by its unique structure, which includes a thiophene ring substituted with an ethyl ester and a trifluoroacetyl group. The presence of the trifluoroacetyl moiety imparts significant polarity and potential reactivity, making it useful in various synthetic applications. The thiophene ring contributes to the compound's aromaticity and stability, while the ethyl ester group enhances its solubility in organic solvents. This compound may exhibit interesting electronic properties due to the electron-withdrawing effects of the trifluoroacetyl group, which can influence its reactivity in electrophilic substitution reactions. Additionally, the presence of fluorine atoms can enhance the compound's lipophilicity and alter its biological activity. Ethyl 5-(2,2,2-trifluoroacetyl)thiophene-2-carboxylate is of interest in medicinal chemistry and materials science, where it may serve as a building block for more complex molecules or as a potential candidate for drug development.

ethyl 5-(2,2,2-trifluoroacetyl)thiophene-2-carboxylate

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Ethyl 5-(trifluoroacetyl)-2-thiophenecarboxylate

Applications 5-(2,2,2-Trifluoroacetyl)-2-thiophenecarboxylic Acid Ethyl Ester is an intermediate in the synthesis of reagents for fluoroacetylthiophene oxadiazoles a class II human histone deacetylase inhibitors.
References Ontoria, J. M., et al.: J. Med. Chem., 52, 6782 (2009);


CAS 898787-39-8: ethyl 5-(2,2,2-trifluoroacetyl)thiophene-2-carboxylate

Ethyl 5-(trifluoroacetyl)-2-thiophenecarboxylate

Ref: 3D-FE91258

5-(2,2,2-Trifluoroacetyl)-2-thiophenecarboxylic Acid Ethyl Ester

Ref: TR-T789755