CAS 90-41-5: 2-Aminobiphenyl

Applications Has a mutagenic potency. References Cash, G., et al.: Mutat. Res., 491, 31 (2001), Cash, G., et al.: Environ. Toxicol. Chem., 21, 2095 (2002), Glende, C., et al.: Mutat. Res., 515, 15 (2002),

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-Aminobiphenyl

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-Aminobiphenyl is a chemical compound with the molecular formula C6H5CH2NH. It has been found to be carcinogenic in animals. 2-Aminobiphenyl is metabolized by the liver and excreted in urine, and is also excreted into breast milk. 2-Aminobiphenyl binds to epidermal growth factor receptors (EGFR) and triggers the activation of cell proliferation. The tissue culture studies show that it induces tumor formation at higher doses, but not at lower doses. 2-Aminobiphenyl has been shown to bind to DNA through intramolecular hydrogen bonds and form adducts with guanine bases. This binding leads to an increase in DNA strand breaks and inhibition of DNA synthesis, which may lead to cancer or other diseases affecting cells that divide rapidly such as bladder cancer or cancer of the skin.