CAS 90-99-3: Chlorodiphenylmethane

Chlorodiphenylmethane is an organic compound. It has two phenyl rings.

Benzhydryl chloride

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Chlorodiphenylmethane is a member of the class of aliphatic hydrocarbons. It is an inhibitor of inflammatory bowel disease and has been shown to be effective in patients with ulcerative colitis. Chlorodiphenylmethane can inhibit inflammatory bowel disease through a number of different mechanisms, including inhibition of the production of cytokines, such as IL-1β and TNF-α, by inhibiting the activation of NF-κB. The mechanism for this inhibition is not fully understood but may involve nucleophilic attack on the carbonyl group on the aromatic ring, which leads to hydrogen fluoride or hydroxyl groups being released from the molecule. The reaction mechanism is thought to be one where hydrogen fluoride or hydroxyl groups are released from the molecule and oxidized radicals are formed. These radicals then react with oxygen in air to form reactive oxygen species (ROS), which cause damage to DNA, proteins, and lipids in

Benzhydryl chloride was used as initiator during the controlled radical polymerization of styrene catalyzed by ionic iron complex. It was also used as the starting reagent in the synthesis of trimethylhydroquinone derivatives. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.