Lipoamide dehydrogenase, with the CAS number 9001-18-7, is an enzyme that plays a crucial role in cellular metabolism, particularly in the oxidative decarboxylation of alpha-keto acids. This enzyme is part of the larger family of flavoproteins and is primarily involved in the regeneration of lipoic acid, which is essential for various enzymatic reactions. Lipoamide dehydrogenase catalyzes the reduction of lipoamide to dihydrolipoamide, utilizing NADH as a reducing agent. It is typically found in the mitochondria of eukaryotic cells and is important for energy production and the metabolism of carbohydrates, fats, and proteins. The enzyme exhibits a high degree of specificity for its substrates and is sensitive to changes in pH and temperature, which can affect its activity. Additionally, lipoamide dehydrogenase is involved in redox reactions, contributing to the cellular antioxidant defense system. Its activity can be influenced by various factors, including the presence of cofactors and inhibitors, making it a subject of interest in biochemical research and potential therapeutic applications.

Lipoamide dehydrogenase

9001-18-7: Dehydrogenase, Lipoamid-, Deshidrogenasa, Lipoamida, Deshydrogenase, Lipoamide, Diaphorase, Dihydrolipoamide dehydrogenase, Dihydrolipoate dehydrogenase, Dihydrolipoic dehydrogenase, Dihydrolipoyl dehydrogenase, Dihydrothioctic dehydrogenase, E.C. 1.6.4.3, E.C. 1.8.1.4, Lipoamide dehydrogenase, Lipoamide dehydrogenase (NADH), Lipoamide oxidoreductase, Lipoamide reductase, Lipoate dehydrogenase, Lipoic acid dehydrogenase, Lipoyl dehydrogenase, α-Lipoamide dehydrogenase, Dehydrogenase, lipoamide

Diaphorase from anaerobic sludge catalyzes RDX biotransformation via denitrification.

Diaphorase

Diaphorase ex. Clostridium Sp., 30U/mg powder

Diaphorase (lipoyl dehydrogenase, EC 1.8.1.4) is an NAD+/NADH-dependent oxidoreductase. One unit of diaphorase will convert 1.0 μmole NADH into NAD+ the presence of substrate at pH 7.5 and 25 °C.

CAS 9001-18-7: Lipoamide dehydrogenase

Diaphorase

Ref: TM-T76114

Diaphorase ex. Clostridium Sp., 30U/mg powder

Ref: SR-90405

Diaphorase

Ref: 7W-GZ6951

Diaphorase (from Clostridium kluyveri)

Ref: 3D-JAA00118

Diaphorase (from Clostridium kluyveri)

Ref: 54-BIB3058