Glucose 6-phosphate isomerase (GPI), also known as phosphoglucose isomerase, is an enzyme that plays a crucial role in carbohydrate metabolism. It catalyzes the reversible conversion of glucose 6-phosphate to fructose 6-phosphate, a key step in both glycolysis and gluconeogenesis. This enzyme is found in various organisms, including bacteria, plants, and animals, highlighting its fundamental importance in energy production and metabolic pathways. GPI is typically a cytosolic enzyme, and its activity is influenced by factors such as pH, temperature, and the concentration of substrates and products. The enzyme is characterized by its specificity for the glucose 6-phosphate substrate and its ability to facilitate the isomerization process efficiently. In addition to its metabolic functions, GPI has been studied for its potential roles in cell signaling and as a tumor marker in certain cancers. The CAS number 9001-41-6 refers to the enzyme's classification in chemical databases, aiding in its identification and study in biochemical research.

Glucose 6-phosphate isomerase

9001-41-6: 6-Phosphoglucose isomerase, <span class="text-smallcaps">D</span>-Glucose-6-phosphate isomerase, D-Glucose-6-phosphate isomerase, E.C. 5.3.1.9, Ec 5.3.1.9, Glucose 6-phosphate isomerase, Glucose 6-phosphate isomerases, Glucose phosphate isomerase, Glucose phosphoisomerase, Glucosephosphate isomerase, Hexose 6-phosphate isomerase, Hexose isomerase, Hexose isomerases, Hexose phosphate isomerase, Hexose phosphate isomerases, Hexose phosphate mutase, Hexose phosphate mutases, Hexosemonophosphate isomerase, Isomerasa, Glucosa Fosfato, Isomerase, Glucose-, Phosphat, Isomerase, Phosphate De Glucose, Oxoisomerase, Phosphoglucoisomerase, Phosphoglucoisomerases, Phosphoglucose isomerase, Phosphoglucose isomerases, Phosphohexoisomerase, Phosphohexoisomerases, Phosphohexomutase, Phosphohexomutases, Phosphohexose isomerase, Phosphohexose isomerases, Phosphosaccharomutase, Isomerase, glucose phosphate

GPI, also PGI or PHI, is a conserved dimeric glycolytic enzyme, catalyzing glucose-6-phosphate to fructose-6-phosphate isomerization.

Glucose-6-phosphate isomerase (GPI, phosphoglucose isomerase/phosphoglucoisomerase, PGI, phosphohexose isomerase, PHI; EC 5.3.1.9) is an enzyme that catalyses isomerisation between Glucose-6-phosphate and Fructose-6-phosphate:  G6P ⇌ F6P  One unit of GPI will convert 1.0 mmole of Fructose-6-phosphate to Glucose-6-phosphate per minute at pH 7.4 and 25 °C.

CAS 9001-41-6: Glucose 6-phosphate isomerase

Glucose 6-phosphate isomerase

Ref: TM-T76152

Phosphoglucose isomerase from baker′s yeast (S. cerevisiae), Type III, ammonium sulfate suspension, ≥400 units/mg protein (biuret)

Ref: 3D-JAA00141