CAS 9003-11-6: Ethylene oxide-propylene oxide copolymer

POLOXAMER 237 CRS

POLOXAMER 338 CRS

POLOXAMER 124 CRS

POLOXAMER 407 CRS

Poloxamer 182 is a non-ionic surfactant that contains dodecyl groups. It has been shown to be an antimicrobial agent and a glycol ether. The anti-bacterial activity of poloxamer 182 is attributed to the benzalkonium chloride, which binds to the bacterial cell membrane and causes depolarization. Poloxamer 182 also has p-gp inhibitory properties, as it competes with substrates for this transporter protein. It has been shown to be used in pharmaceutical drugs and cardiotonic agents. This drug also inhibits cancer cell viability when it interacts with phospholipids on their surface, making them more susceptible to lysis by other cells. Poloxamer 182 has been used as a particle in analytical methods such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry, where it acts as a chemical stabilizer.

Lubricant in metal working; anti-foaming aid; surface cleanser.  Average MW 5800

Pluronic P84 is an amphiphilic non-ionic surfactant that is used as a pesticide, solvent, and emulsifying agent. The solubility of Pluronic P84 in water increases with the addition of ethylene glycol and decreases with temperature. This product also has a low surface tension and can be used for osmosis experiments. Pluronic P84 has been shown to have antibacterial activity against Staphylococcus aureus, which may be due to its ability to inhibit protein synthesis.

Organic surface active agents,other,aromatic or modified aromatic

Poloxamer 268 is a nonsteroidal anti-inflammatory drug that belongs to the class of glycol ethers. It has been shown to have an inhibitory effect on matrix metalloproteinases, which are enzymes that degrade extracellular matrix components. The antimicrobial activity of Poloxamer 268 has been demonstrated in vitro and in vivo. In one study, it was found that Poloxamer 268 had a protective effect against skin cancer cells, with no toxic effects on other skin cells. In another study, it was found to be effective against microbial infection and myocardial infarcts in rats. The receptor binding property of Poloxamer 268 has also been studied using tryptophan fluorescence spectroscopy and anti-PCSK9 antibody binding studies. Poloxamer 268 has been shown to bind to the fatty acid receptor GPR120 and activate peroxisome proliferator-activated receptors (PPAR)α and PPARγ, which regulate lipid metabolism

PEG-PP-PEG is a nonsteroidal anti-inflammatory drug that acts as a surfactant, detergent, and emulsifier. It is used to treat inflammation and pain in the joints, muscles, and bones. PEG-PP-PEG is also used as a food additive for products such as ice cream, cheese, whipped cream, and salad dressings. This compound is not absorbed by the human body and does not cause any side effects because it does not bind to proteins or nucleic acids.

Cationic organic surface-active agents,other than aromatic or modified aromatic, whether or not for retail sale, non-ionic, nesoi

Cell membrane stabilizer; anti-foaming agent

407; Cell membrane stabilizer; anti-foaming agent

Pluronic L101 is a non-ionic surfactant. It has shown to be a P-glycoprotein (P-gp) inhibitor, which may be due to its chemical stability and ability to bind to the cell membrane. Pluronic L101 also has been shown to inhibit the growth of skin cancer cells by binding to the cell membrane and preventing the uptake of glycol ethers. The surfactant is also an antimicrobial agent that can inhibit bacteria such as Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The most common use for this product is in skin care products such as lotions and sunscreens. Pluronic L101 has been shown to have anti-inflammatory properties that are stronger than those of ibuprofen or aspirin when tested on rats with myocardial infarcts. This product is also used in analytical methods for measuring P-gp substrate concentrations in human

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) is a polymeric drug that has been synthesized to inhibit the activity of P-glycoprotein. This polymer is used to control the uptake of drugs into cells. It also has shown an effect on cancer cell viability, ATP levels, and hydrogen bond formation in vitro. Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) has also been found to be a nonsteroidal anti-inflammatory drug (NSAID). NSAIDs are used for the treatment of pain and inflammation caused by diseases such as osteoarthritis or rheumatoid arthritis. NSAIDs work by inhibiting cyclooxygenase, which is an enzyme that produces prostaglandins from arachidonic acid. The inhibition of prostaglandin synthesis leads to reduced inflammation and pain. NSAIDs can cause side effects

Poloxamer 407 is a nonionic surfactant.

Pluronic L62 is a surfactant that is used to prevent air bubbles from forming in contact lens solutions. It is composed of synthetic block copolymers, which are a type of polymer with both hydrophobic and hydrophilic segments. Pluronic L62 can be used as an anti-inflammatory agent by inhibiting the production of prostaglandins, which are inflammatory mediators. This drug also has been shown to reduce choroidal neovascularization in mice by inhibiting vascular endothelial growth factor (VEGF). In vivo bioavailability data on pluronic L62 has not yet been published.

Pluronic P65 is a non-ionic surfactant that has the ability to disperse, wet, and stabilize a variety of materials. It is used as an additive in many products such as cosmetics, pharmaceuticals, and food. Pluronic P65 is bifunctional in that it can be both hydrophilic (water soluble) and lipophilic (fat soluble). This allows for its use in acid solutions and in diethylene glycol. Pluronic P65 also has the ability to reduce surface tension by adsorbing onto the surface of water droplets. This property makes it useful in ophthalmic solutions as well as microscopy studies. The diameter of these particles is 1-5 nanometers, making them optimal for optical purposes.