CAS 9024-13-9: Chondroitin-sulfate-ABC endolyase

Chondroitinase ABC is a bacterial enzyme, which is derived from Proteus vulgaris with the ability to degrade glycosaminoglycans, specifically targeting chondroitin sulfate, dermatan sulfate, and hyaluronic acid. This enzyme's mode of action involves the enzymatic cleavage of β-1,4 linkages between N-acetylgalactosamine and glucuronic acid residues in chondroitin sulfate, resulting in the breakdown of these polyanionic molecules into disaccharides. The principal applications of Chondroitinase ABC are within the fields of neurobiology and regenerative medicine. It is extensively utilized in research focused on the central nervous system, particularly for its potential in promoting neural regeneration following injuries. By degrading the inhibitory chondroitin sulfate proteoglycans in the extracellular matrix of the central nervous system, Chondroitinase ABC facilitates axonal growth and plasticity. Similarly, in cartilage research, it is used to investigate the structural-functional aspects of proteoglycans in connective tissues. The enzyme's specificity and efficacy make it a valuable tool for elucidating the complex roles of glycosaminoglycans in pathological and physiological conditions.