![2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-carboxamide, dihydrochloride salt](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fcas-image%2Fthumb-webp%2F405225-2-2r-2-methylpyrrolidin-2-yl-1h-benimidazole-4-carboxamide-dihydrochloride-salt.webp&w=3840&q=75)
CAS 912445-05-7: 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-carboxamide, dihydrochloride salt
Formula:C13H18Cl2N4O
InChI:InChI=1/C13H16N4O.2ClH/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12;;/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17);2*1H/t13-;;/m1../s1
SMILES:C[C@@]1(CCCN1)c1nc2cccc(c2[nH]1)C(=N)O.Cl.Cl
Synonyms:- ABT-888.2HCl
- Veliparib 2HCl
- 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide dihydrochloride
- Veliparib dihydrochloride
Sort by
Found 4 products.
Veliparib dihydrochloride
CAS:Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.Formula:C13H18Cl2N4OPurity:97.09% - 98%Color and Shape:SolidMolecular weight:317.21Veliparib dihydrochloride
CAS:Veliparib is a pan-inhibitor of polymerase chain reaction (PCR) that inhibits the enzyme DNA polymerase. It has been shown to induce neuronal death and inhibit cell growth in vitro, as well as to reduce tumor size in vivo. Veliparib binds to the active site of DNA polymerase, thereby inhibiting its activity. The binding mechanism is competitive with respect to ATP and is reversible. Veliparib has been shown to be an effective inhibitor of Jak2 in v617F cells, which are found in about 15% of all solid tumours. Veliparib also inhibits the expression of proteins involved in cellular proliferation, such as cyclin D1 and c-Myc, which are associated with increased cancer risk.Formula:C13H16N4O·2HClPurity:Min. 95%Molecular weight:317.21 g/mol
