(Nle27)-GRF (1-29) amide, also known as human Growth Hormone-Releasing Factor, is a synthetic peptide that mimics the natural growth hormone-releasing hormone (GHRH) produced in the hypothalamus. This compound consists of 29 amino acids, with the substitution of norleucine (Nle) at the 27th position, enhancing its stability and potency. It functions primarily by stimulating the secretion of growth hormone from the anterior pituitary gland, thereby playing a crucial role in growth, metabolism, and overall endocrine function. The amide modification at the C-terminus contributes to its increased resistance to enzymatic degradation, making it more effective in therapeutic applications. This peptide is often utilized in research settings to study growth hormone dynamics and has potential implications in treating growth hormone deficiencies. Its CAS number, 91869-58-8, uniquely identifies this compound in chemical databases, facilitating its recognition in scientific literature and regulatory contexts. Overall, (Nle27)-GRF (1-29) amide represents a significant advancement in peptide therapeutics related to growth hormone regulation.

(Nle27)-GRF (1-29) amide (human)

91869-58-8: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Nle-Ser-Arg-NH2

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CAS 91869-58-8: (Nle27)-GRF (1-29) amide (human)

(Nle 27)-GRF (1-29) amide (human)

Ref: 3D-FN109696