CAS 924-16-3: N-Nitrosodibutylamine

N-Nitroso-di-n-butylamine is a nitrosamine that is a product of wastewater treatment. It has been shown to inhibit mitochondrial function and induce liver lesions in rats at high doses. N-Nitroso-di-n-butylamine is structurally similar to the natural substrate ribose, which leads to inhibition of xanthine oxidase, an enzyme involved in purine metabolism. The structural analysis revealed the presence of reactive sites that are susceptible to attack by nucleophiles, such as hydroxyl radicals or hydrogen peroxide. This indicates that N-Nitroso-di-n-butylamine may be a precursor for other carcinogenic compounds. NADH is reduced by NADH dehydrogenase (complex I) in mitochondria to produce NAD+, which subsequently donates electrons to the electron transport chain and generates ATP. The ability of NNDB to inhibit complex I activity was assessed using hl60