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ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.

ABP 688 is a radiolabeled ligand, which is a synthetic compound used primarily in positron emission tomography (PET) to visualize metabotropic glutamate receptor subtype 5 (mGluR5) in vivo. Developed from chemical synthesis, ABP 688 acts by selectively binding to the allosteric site of the mGluR5 receptor with high affinity and specificity. When labeled with a positron-emitting isotope such as Carbon-11 or Fluorine-18, it allows for the non-invasive imaging and quantification of mGluR5 distribution and density in the brain. The primary use of ABP 688 is in neuroscience research, where it aids in the study of neurological and psychiatric disorders associated with glutamatergic dysfunction, such as schizophrenia, depression, and addiction. By providing detailed insights into mGluR5 expression patterns, this radioligand facilitates the understanding of pathophysiological mechanisms and the evaluation of therapeutic interventions targeting mGluR5. ABP 688 is not used for therapeutic purposes but remains a crucial tool in translational research bridging preclinical studies and human clinical trials.

ABP688