CAS: 924811-53-0

Activator of RET signalling cascade and a derivative of a GFL mimetic compound BT 13. Molecular docking calculations and molecular dynamics simulations were performed in GDNF−GFRα1−RetA complex and showed that BT 18 binds to the allosteric site in GFRα1 as well as RetA surface interfacing GFRα1.

BT18 mimics GDNF, affecting RET receptor tyrosine kinase RetA and GFRα1 function.

BT18