CAS: 928151-78-4

Tenacissoside F is a newly identified steroidal glycoside。Its homologous compound Tenacissoside G can inhibit P-gp and block HepG2 cells in G1/S phase.

Tenacissoside F is a triterpenoid saponin, which is a naturally occurring compound isolated from the plant genus *Marsdenia*. These plants have been traditionally used in herbal medicine, and the compound is extracted through advanced chromatographic techniques from the plant's tissues. The mode of action of Tenacissoside F involves the modulation of various cellular pathways that regulate cell proliferation and apoptosis. Specifically, it has been shown to induce mitochondrial-mediated apoptosis, inhibit the NF-κB signaling pathway, and affect the expression of proteins involved in cell cycle regulation. Tenacissoside F's potential applications are primarily in the field of oncology research. Its ability to selectively induce apoptosis in cancer cells holds promise for the development of novel anticancer therapies. Additionally, ongoing studies are exploring its potential synergistic effects when combined with other chemotherapeutic agents, making Tenacissoside F a compound of significant interest in the development of multi-targeted cancer treatment strategies. As research progresses, further elucidation of its mechanisms may expand its applications in various therapeutic contexts.