Nitrosohexamethylenimine, with the CAS number 932-83-2, is an organic compound characterized by the presence of a nitroso functional group (-NO) attached to a hexamethylenimine backbone. This compound typically appears as a colorless to pale yellow liquid or solid, depending on its physical state at room temperature. It is known for its potential applications in organic synthesis and as a reagent in various chemical reactions, particularly in the formation of nitrogen-containing compounds. The presence of the nitroso group imparts unique reactivity, allowing it to participate in electrophilic reactions. Additionally, nitroso compounds are often associated with biological activity, which may include antimicrobial properties. However, handling such compounds requires caution due to their potential toxicity and reactivity. Proper safety measures should be observed, including the use of personal protective equipment and working in a well-ventilated area or fume hood. Overall, nitrosohexamethylenimine is a notable compound in the field of organic chemistry, with specific characteristics that make it of interest for further research and application.

Nitrosohexamethylenimine

932-83-2: N-Nitrosoperhydroazepine, Brn 1237798, Ccris 468, Hexahydro-1-nitroso-1H-azepine, N-6-Mi, N-Nitrosoazacycloheptane, N-Nitrosohexahydroazepine, Nitrosohexamethyleneimine, Nitrosohexamethylenimine, 1H-Azepine, hexahydro-1-nitroso-, N-Nitrosohexamethylenimine, 1-Nitrosoazepane,  N-Nitrosohexamethyleneimine,  5-20-04-00067 (Beilstein Handbook Reference)

1-Nitrosoazepane is a cytotoxic agent that is used in the treatment of severe forms of cancer. It has been shown to cause cervical and vaginal cancers in rats, but not in mice. 1-Nitrosoazepane is also known to be teratogenic, causing birth defects in rat fetuses and hamsters. This drug binds to DNA and activates the cellular enzyme hydroxylase, which converts it into a reactive form that causes DNA damage. The cytotoxic activity of 1-nitrosoazepane is due to its ability to react with DNA and other macromolecules. This reactive form can be further oxidized by radiation or hydrogen peroxide, leading to cell death by apoptosis.

1-Nitrosoazepane

Applications N-Nitrosohexamethylenimine is a carcinogen.
References Goodall, C. M., et al.: Toxicology, 33, 251 (1984); Lijinsky, W., et al.: J. Cancer Res. Clin. Oncol., 108, 46 (1984); Goodall, C. M., et al.: JNCI, J. Natl Cancer Inst., 73, 1215 (1984)


CAS 932-83-2: Nitrosohexamethylenimine

1-Nitrosoazepane

Ref: 3D-AAA93283

N-Nitrosohexamethylenimine

Ref: TR-N546585

N-NITROSOHEXAMETHYLENEIMINE

Ref: IN-DA00GRRQ