CAS 933-67-5: 7-Methylindole

7-Methylindole is a chemical compound with the formula C8H7N. It is a colorless solid with a pleasant aromatic odor. It is used as a building block in organic chemistry and as a reagent for organic synthesis. 7-Methylindole can be converted to other compounds through reactions with various reagents, such as halogens and hydrogen halides, nitrous acid, alkylating agents, and sulfur dioxide. The resulting products are useful research chemicals or natural products. 7-Methylindole is also used to produce indigo dye from indigo blue pigment.

It is a reactant for preparation of pharmaceutically active pyrrolidine analogues via Markovnikov addition, tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators, plant growth inhibitors, antifungal agents, sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes and inhibitors of HIV-1 attachment. It is a reactant for Friedel-Crafts alkylation reactions and reductive formylation reactions. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

7-Methyl-1H-indole

Applications 7-Methylindole is a reactant in the synthesis of α-amino amides that are found in a variety of biological-active compounds. References Box, H.K., et. al.: Tetrahedron, 70, 9709 (2014)

7-Methylidole is a heterocyclic chemical compound that is used as a precursor in the synthesis of many pharmaceuticals. It has been shown to have an inhibitory effect on the growth of cancer cells in tissue cultures and can be used as a marker for cancer cells. 7-Methylidole is also a virulence factor, which can be seen through assays on bacterial strains. This compound has been proven to be reactive with Polygonum cuspidatum. The reaction produces indirubin, which is a red pigment that is found in some species of Polygonum and other plants.

7-Methylindole is a biochemical substance that is synthesized in the body. It is produced in the liver, and it can be found in the brain, heart, and kidney. 7-Methylindole has been shown to have cancer-fighting properties. 7-Methylindole binds to DNA by methylating nucleic acid bases, which causes a change in the genetic code. This leads to tumor cells being more sensitive to treatment with other substances that inhibit DNA synthesis or repair, such as anthranilate and 5-methoxyindole.