CAS: 936233-18-0

N'-(1-Carboxymethyl)-L-lysine-d5 is a reactive analog of L-lysine. It can be used to study the metabolic rate in animals. This compound can also be used to examine mitochondrial function and the effects of dietary polyunsaturated fatty acids on DNA damage. N'-(1-Carboxymethyl)-L-lysine-d5 is a marker for oxidative damage to nuclear DNA, which is especially useful for evaluating diabetic patients. This compound has been found to be an important marker for glomerular filtration rate in rats.

Stability Hygroscopic Applications CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions. References Fu, M.X., et al.: J. Biol. Chem., 271, 9982 (1996), Ahmed M.U., et al.: Biochem.J., 324, 565 (1997), Schleicher, E.D., et al.: J. Clin. Invest., 99, 457 (1997), Shibayama, R., et al.: Diabetes, 48, 1842 (1999),