CAS 942-24-5: Methyl indole-3-carboxylate

Methyl indole-3-carboxylate

Methyl indole-3-carboxylate (Methyl 3-indolecarboxylate) is a natural product isolated from Heracleum candicans.

Indole-3-carboxylic acid methyl ester is a quinoline derivative that is structurally related to the well-known antibiotic, ciprofloxacin. It has been shown to be cytotoxic against a variety of bacterial strains including Pseudomonas aeruginosa and Staphylococcus aureus. The mechanism of action for this compound is not yet fully understood, but it has been shown to inhibit collagen production in cell cultures and induce neuronal death in mice. Indole-3-carboxylic acid methyl ester also possesses anti-cancer properties and inhibits fatty acid synthesis. This compound also has antifungal effects against Candida albicans and other fungi.

Methyl indole-3-carboxylate

Reactant used for preparation of nitric oxide synthesis (nNOS) inhibitors, protein kinase c alpha (PKCα) inhibitors, inhibitors of the C-terminal domain of RNA polymerase II as antitumor agents, kinase insert domain receptor (KDR) inhibitors, organocatalysts for the anti-Mannich reaction, very late antigen-4 (VLA-4) antagonists, inhibitors of Human 5-Lipoxygenase, serotonin 5-HT4 receptor antagonists and hyaluronidase inhibitors. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications Methyl indole-3-carboxylate is a reagent in the preaparation of oncrasin-1 derivatives which is a novel inhibitor of the C-terminal domain of RNA polymerase II. References Wu, S., et al.: J. Med. Chem., 54, 2668 (2011);