CAS 942206-85-1: Gsk 10116790A
Formula:C28H32Cl2N4O6S2
InChI:InChI=1S/C28H32Cl2N4O6S2/c1-17(2)13-21(31-26(36)24-14-18-5-3-4-6-23(18)41-24)27(37)33-9-11-34(12-10-33)28(38)22(16-35)32-42(39,40)25-8-7-19(29)15-20(25)30/h3-8,14-15,17,21-22,32,35H,9-13,16H2,1-2H3,(H,31,36)/t21-,22-/m0/s1
InChI key:InChIKey=IVYQPSHHYIAUFO-VXKWHMMOSA-N
SMILES:C(N[C@H](C(=O)N1CCN(C([C@@H](NS(=O)(=O)C2=C(Cl)C=C(Cl)C=C2)CO)=O)CC1)CC(C)C)(=O)C3=CC=4C(S3)=CC=CC4
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Found 6 products.
GSK1016790A
CAS:Formula:C28H32Cl2N4O6S2Purity:≥ 97%Color and Shape:White solidMolecular weight:655.61N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide
CAS:Formula:C28H32Cl2N4O6S2Purity:98%Color and Shape:SolidMolecular weight:655.6129GSK1016790A
CAS:GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelialFormula:C28H32Cl2N4O6S2Purity:96.25% - 99.05%Color and Shape:SolidMolecular weight:655.61Ref: TM-T6848
1mg37.00€2mg48.00€5mg72.00€10mg113.00€25mg240.00€50mg364.00€100mg540.00€1mL*10mM (DMSO)97.00€GSK 1016790A
CAS:Controlled ProductApplications GSK 1016790A is a transient receptor potential vanilloid 4 (TRPV4) agonist. References Egbuniwe, O., et. al.: J. Dent. Res., 93, 911 (2014); Yamawaki, H., et. al.: Am. J. Phys., 307, g33 (2014)Formula:C28H32Cl2N4O6S2Color and Shape:NeatMolecular weight:655.61GSK1016790A
CAS:GSK1016790A is a potent and selective small molecule inhibitor of TRPV4, a member of the transient receptor potential (TRP) channel family. It is currently being investigated for pharmacological effects in vitro and in vivo. GSK1016790A has been shown to inhibit the activity of TRPV4 channels in neuronal cells, leading to an increase in intracellular calcium levels and subsequent neuronal death. This agent also blocks the angiotensin system, which may have physiological implications including regulation of blood pressure. GSK1016790A binds to calcium binding sites on the cytosolic side of TRPV4 channels where it acts as a competitive antagonist. The compound is stable over a wide pH range and does not show any significant effect on cellular viability at concentrations up to 100 µM.Formula:C28H32Cl2N4O6S2Purity:Min. 95%Molecular weight:655.61 g/mol
