CAS: 943250-66-6

Impurity Lopinavir EP Impurity R Applications (αS)-3-[2-(2,6-Dimethylphenoxy)acetyl]-N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide (Lopinavir EP Impurity R) is an impurity of Lopinavir (L469480), a selective HIV protease inhibitor. References Chitturi, S.R., et al.: J. Pharma. Biomed. Anal., 48, 1430 (2008); Devi, A.S.L., et al.: Magnet. Reson. Chem., 45, 424 (2007);

Lopinavir Impurity R is a research and development impurity standard. It is synthesized as a white solid. Lopinavir Impurity R has been used in the synthesis of lopinavir, an HIV protease inhibitor. Lopinavir Impurity R is a metabolite of lopinavir and can be found in the urine and plasma of patients taking the drug. This impurity standard has been shown to have pharmacological activity on metabolism studies, but its role in drug development has not been determined.