CAS 943319-70-8: Ponatinib
Formula:C29H27F3N6O
InChI:InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
InChI key:InChIKey=PHXJVRSECIGDHY-UHFFFAOYSA-N
SMILES:C(#CC1=CC(C(NC2=CC(C(F)(F)F)=C(CN3CCN(C)CC3)C=C2)=O)=CC=C1C)C=4N5C(=NC4)C=CC=N5
Synonyms:- 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide
- Ap 24534
- Ap24534
- Benzamide, 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-
- Iclusig
- Ponatinib
- AP24534(Ponatinib)
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Found 8 products.
Ponatinib
CAS:Controlled ProductApplications Ponatinib is a tyrosine kinase inhibitors (TKI) and used to treat chronic myeloid leukemia (CML) (1,2,3). Ponatinib is also used in combination with other drugs, such as forskolin, to combat TKI resistance in patient with CML (3), targeted drug in small-cell lung cancer. Potent FAK inhibitor. FGFR/VEGFR/Bcr-Abl inhibitor It is a COVID19-related research product. References (1) Poch, M. M., et al.: Expert Rev Hematol. 9, 923 (2016) (2) Shamroe, C. L. and Comeau, J. M. Ann Pharmacother. 47, 1540 (2013)(3) Oaxaca, D. M., et al.: Tumour Biol. 37, 12643 (2016)Formula:C29H27F3N6OColor and Shape:Off-WhiteMolecular weight:532.56Ponatinib
CAS:BCR-ABL1 tyrosine kinase inhibitorFormula:C29H27F3N6OPurity:Min. 95%Color and Shape:PowderMolecular weight:532.56 g/molPonatinib
CAS:Formula:C29H27F3N6OPurity:≥ 98.0%Color and Shape:White or off-white powder or crystalsMolecular weight:532.56Ponatinib, Free Base
CAS:Ponatinib, Free BaseFormula:C29H27F3N6OPurity:98%Color and Shape: off-white crystalline solidMolecular weight:532.56g/molPonatinib Glucuronide
CAS:Controlled ProductFormula:C35H35F3N6O7Color and Shape:NeatMolecular weight:709.692Ponatinib
CAS:Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectivelyFormula:C29H27F3N6OPurity:98% - 99.60%Color and Shape:SolidMolecular weight:532.56
