CAS: 945714-67-0

FPS-ZM1 is a small molecule drug with immunomodulatory and anti-inflammatory properties. It was originally synthesized as an inhibitor of the transcriptional regulator HMG-BOX, which is found in the promoters of genes involved in neuronal death, inflammation, and autoimmune diseases. FPS-ZM1 inhibits the transcriptional regulator HMG-BOX by binding to it, thereby preventing it from interacting with its DNA target. This inhibition leads to decreased expression of proinflammatory genes. The effects of FPS-ZM1 on inflammatory responses have been demonstrated in vitro and in vivo using human cells. In addition, FPS-ZM1 has been shown to inhibit Toll-like receptor (TLR) signaling pathways that are activated by lipopolysaccharide (LPS).

FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.

FPS-ZM1